Phytoconstituent based interventions for gastric ulcer management: A review of efficacy and mechanisms

Peptic ulcer is a very common disease of the gastrointestinal system that can cause serious health problems like internal bleeding, perforations and obstruction. In India, it affects about 5 to 10% of the population, particularly men in their fifties. Main cause of peptic ulcers is H. Pylori infection and inappropriate use of non-steroidal anti-inflammatory medications. Traditional treatment is becoming ineffective due to the development of resistance in H.Pylori. Newer strategies can focus on natural products that are derived from plants. Phytochemicals like alkaloids, flavonoids and saponins present in extracts can promote healing of ulcers by their anti-microbial activity, free radical scavenging effects and anti-inflammatory property.