Volume: 11, Issue: 2

ABSTRACT

Alzheimer's disease is the major cause of dementia which leads to impairment of memory, thinking, and behavior, primarily affecting individuals aged 65 and older. Genetic factors, including variations in the apolipoprotein E (APOE) gene, and the aggregation of amyloid plaques and tau tangles, are key contributors to the disease. Some Environmental and lifestyle factors, such as diet, exercise, and cognitive engagement, also affect the risk. With the aging global population, the spread of Alzheimer's is projected to elevate from 50 million to over 150 million by 2050. Diagnosis involves medical history, cognitive tests, and brain imaging, though definitive diagnosis is post-mortem. Treatments include cholinesterase inhibitors and memantine to manage symptoms. The increasing prevalence highlights the need for ongoing research into Alzheimer's mechanisms and interventions.

Keywords

Alzheimer, dementia, amyloid plaques