Unravelling the therapeutic potential of Lantana camara in skin cancer

Natural products and their metabolites have a historical significance as they serve as a starting point for drug discovery and development process. Lantana camara, a notorious invasive weed has been used in folk medicine for managing various health concerns. Pentacyclic triterpenoids (Lantadenes), have attracted significant interest due to their anticancer potential. The present study include in vivo anticancer investigations of 3β-(4-Methoxybenzoyloxy)-22β-senecioyloxy-olean-12-en-28-oic acid using two-stage carcinoma model. This compound showed notable anticancer potential, evidenced by a substantial reduction in tumour burden and volume along with attenuation in proliferation, thickness, and corrugation of epidermis in cancer model. These findings indicate Lantadene structural modification may hold substantial potential against skin malignancies.