Inflammation and aging: Unraveling cellular signals and innovative therapies

As we grow older, our body starts to experience persistent, low grade inflammation- referred to as inflammaging. Unlike the acute responses which promotes healing, this chronic inflammation acts as a wildfire which leads to initiation and progression of various age-related disorders including cardiovascular disease, metabolic and neurological disorders. Inflammaging arises as a result of combination of complex overlapping processes- cellular senescence, gradual weakening of the immune system (immunosenescence) and build up of cellular stress and damage. These process together create a self-reinforcing cycle that along with driving aging at cellular level also contributes in overall physical and mental decline. The article explores how inflammaging impacts different organs and tissues in the body. Additionally, it highlights the promising therapeutic strategies such as senolytic drugs, anti-inflammatory compounds, life-style modification, which aims at restoring healthy body and support resilient aging.