A novel frontier in computational approaches and personalised medicine interventions to overcome antibiotic resistance

The growing increase in antibiotic resistance is a health catastrophe that poses a direct challenge to global health. Programmes like Global Antimicrobial Resistance Surveillance System under WHO (World Health Organization), Global Health Security Agenda (GHSA), and Antimicrobial Resistance Action Package (GHSA Action Package Prevent-1) were created to address this problem (1). Antibiotics, sometimes called "miracle drugs," have prevented the needless deaths of many people from bacterial infections or diseases. The evolution of antibiotic-resistant bacteria, however, has been fuelled by the extensive and often improper use of antibiotics in human and animal healthcare and in agriculture (2). Some bacterial strains have developed resistance to antibiotics, making these life-saving medications useless against bacterial infections that were formerly readily treated (1). Bacteria are incredible survivors because of their innate capacity to adjust to new conditions, including exposure to antibiotics (3).