Unveiling and understanding omphalitis: An obscure orphan disease in new-borns

Omphalitis is a serious infection of the umbilical cord stump, often caused by Staphylococcus aureus and other bacteria, leading to complications such as necrotizing fasciitis. This review highlights the etiology, and diagnostic approaches associated with omphalitis, with a particular focus on Staphylococcus aureus infections. Clinical cases from different countries illustrate variability in management of omphalitis. Additionally, insights into the potential use of umbilical cord blood stem cells as a future therapeutic approach are discussed, suggesting approach for personalized medicine.