Mechanistic Approaches for Combating against Antibiotic Resistance

The discovery of antibiotics was one of the milestones in human history since it revolutionized the world of medicine in many ways and helped save innumerable lives. Fundamentally, antibiotics are from natural origin; a deep understanding of the chemical structure, biosynthetic routes, evolution, and mode of action of the many antibiotic compounds is however, required. Due to its complex structure with respect to the functional groups and chiral nature, it is challenging to perform the total synthesis of these compounds in the lab. During the history of antibiotics, research on modes of action has offered biochemical knowledge on these ligands and their microbial targets (1, 2).