Implementation of skin-on-a-chip technology in pre-clinical evaluation of cosmetics and topical pharmaceuticals

Abstract Skin-on-a-chip (SOC) models are emerging as next-generation tools in the preclinical evaluation of cosmetics and pharmaceutical compounds. These models accurately replicate the 3D anatomical organization and physiological functions of human skin. Additionally, they are more economical and realistic as compared to the conventional 2D cell culture systems and animal models. Engineering an ideal skin equivalent requires construction of a SOC system wherein the anatomical development of in vitro human skin is integrated with a microfluidic assembly, so that it can comprehensively mimic the in-vivo complexity, functionality and flow conditions. SOCs are based on the principle of 3Rs i.e., replacement, reduction, and refinement (RRR) in animal models to support more humane scientific experiments. In this article, we have briefly discussed about the SOC technology. Further, we have reviewed the application of this technology in pre-clinical investigations of new topical pharmaceutical and cosmetic molecules to accelerate their transition into markets. Keywords: Skin-on-a-chip (SOC); preclinical; cosmetics; pharmaceuticals; microfluidic