Emerging avenues of flavonoids in defying antibiotic resistance

Antibiotic resistance is a critical issue in the clinical use of antibiotics for the management of bacterial infections, as well as more serious conditions such as cancer (1). The growing development and spread of multidrug resistant infections has accelerated the demand for novel antibiotics, directing research focus towards natural compounds, such as flavonoids (2). Flavonoids are bioactive with tremendous health potentials and are widely present in a variety of food materials, such as fruits and vegetables. Some of the most studied benefits include antioxidant and anti-inflammatory activities, and their impact on biological functioning has been validated through a variety of preclinical and clinical studies (3). The topic at hand deals with the possibilities of harnessing flavonoids in the management of antimicrobial resistance, and the authors have aimed to provide a structured understanding of the phenomenon and prospective intervention strategies.