Bio-Engineered Cell Based Functional Systems as Next Generation for Cancer Therapeutics

Abstract Cell based therapy with enthusiastic capability of intrinsic homing tumor sites with noticeable on-board sensing ability helps to design the way towards the target in fatal as well as intractable disease like cancer. Structurally engineered, these cell-based systems are equipped with sensing functionality which allows them to follow the cues to reach tumor microenvironment, that potentially frames them as advanced ideal candidates in smart cancer therapeutics. The discussed review presents the highlights of all the progress and advancements on the most promising cancer cell-based therapy as targeted theragnostic including genetically engineered materials and techniques in stem cell therapy, CAR-T cell therapy, NK-cell immune therapy, as emerging era on the horizon. Keywords: Cancer cell-based therapy, CAR-T cell therapy, NK-cell immune therapy