Use of the cell-based treatment for inflammation triggered depression

Abstract With a variety of immunophenotypic profiles, isolation methods, modes of action, and regulatory levels, cell therapy comprises stem cell and non-stem cell-based, unicellular, and multicellular therapies. Antidepressant- based conventional therapy is ineffective for about one-third of depressed patients. The use of mesenchymal stem cell therapy to treat depression is one of several potential non-pharmacological treatments that have been researched recently. Since it is clinically pertinent to create novel treatments to treat psychiatric patients, these therapies are reviewed here. Based on its anti-inflammatory and neurotrophic qualities, experimental findings support the idea that mesenchymal stem cell therapy could be regarded as a possible treatment for depression. However, there are several ongoing clinical trials using stem cells to treat depression, but no findings have been made public. To determine how much mesenchymal stem cells can be used in psychiatric clinics as a technique for aiding depression treatment, this review and other upcoming clinical investigations will be significant. Keywords: Call therapy, Depression, Inflammation, Mesenchymal stem-cell transplant.